Phospho-Jak Family (Tyr1007/1008) (E9E4O) Rabbit Antibody
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Phospho-Jak Family (Tyr1007/1008) (E9E4O) Rabbit Antibody

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CAT. NO.: AMA-0456

Target Information
UniProt ID O60674
Product Details
Size 100 µL
Reactivity Human, Mouse
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007/Try1008 of human Jak2 protein.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 115-135 kDa
Background
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats Shc insulin receptor substrates and focal adhesion kinase (FAK) typically contain SH2 or other phospho-tyrosine-binding domains.

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