CAT. NO.: AMA-0371
| Target Information | |
|---|---|
| UniProt ID | Q05397 |
| Product Details | |
|---|---|
| Size | 20 µL/100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 125 kDa |
| Background | |
|---|---|
| Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK. | |
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