Phospho-Erk1/2 Antibody

INQUIRY

CAT. NO.: AMA-0231

Product Details
Size	100 µg
Reactivity	Human, Mouse, Rat
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C.
Purification	Affinity purified

Usage
Application	WB, IHC
Product Usage Information Dilution	Western Blotting (0.5-4 µg/ml); Immunoprecipitation (10-20 µg/mL); Immunohistochemistry (10-20 µg/mL)

Background
Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of cell growth and differentiation. Activation of MAP kinases occurs throμgh phosphorylation of threonine and tyrosine (202 and 204 of human MAP kinase [Erk1] or 183 and 185 of rat Erk2) at the sequence TEY by a single upstream MAP kinase kinase (MEK). Both kinases are known to weakly autophosphorylate on tyrosine.

Background

Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of cell growth and differentiation. Activation of MAP kinases occurs throμgh phosphorylation of threonine and tyrosine (202 and 204 of human MAP kinase [Erk1] or 183 and 185 of rat Erk2) at the sequence T*EY* by a single upstream MAP kinase kinase (MEK). Both kinases are known to weakly autophosphorylate on tyrosine.

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.