CAT. NO.: AMA-0701
| Target Information | |
|---|---|
| UniProt ID | P06493 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr15 of human cdc2. |
| Usage | |
|---|---|
| Application | F |
| Product Usage Information Dilution | Flow Cytometry (1:50) |
| Background | |
|---|---|
| The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of cdc2 at Thr14 and Tyr15 Phosphorylation at Thr14 and Tyr15, resulting in inhibition of cdc2, can be carried out by Wee1 and Myt1 protein kinases The cdc25 phosphatase may be responsible for removal of phosphates at Thr14 and Tyr15 and subsequent activation of cdc2. | |
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