Phospho-Bad (Ser136) (D25H8) Rabbit Antibody
Online Inquiry

Phospho-Bad (Ser136) (D25H8) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0494

Target Information
UniProt ID Q92934
Product Details
Size 20 µL/100 µL
Reactivity Human, Mouse, Monkey
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser136 of mouse Bad protein.
Usage
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:100)
MW (Target) 23 kDa
Background
Bad is a proapoptotic member of the Bcl-2 family that promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL Survival factors, such as IL-3, inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser136 Phosphorylation at these sites promotes binding of Bad to 14-3-3 proteins to prevent an association between Bad with Bcl-2 and Bcl-xL Akt phosphorylates Bad at Ser136 to promote cell survival Bad is phosphorylated at Ser112 both in vivo and in vitro by p90RSK and mitochondria-anchored PKA Phosphorylation at Ser155 in the BH3 domain by PKA plays a critical role in blocking the dimerization of Bad and Bcl-xL.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.