CAT. NO.: AMA-0254
| Product Details | |
|---|---|
| Size | 400 µL |
| Reactivity | All Species |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with synthetic phospho-Akt substrate peptides. |
| Usage | |
|---|---|
| Application | IP |
| Product Usage Information Dilution | Immunoprecipitation (1:20) |
| Background | |
|---|---|
| An important class of kinases, referred to as Arg-directed kinases or AGC-family kinases, includes cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase (PKG), protein kinase C, Akt, and RSK. These kinases share a substrate specificity characterized by Arg at position -3 relative to the phosphorylated Ser or Thr. Akt plays a central role in mediating critical cellular responses including cell growth and survival, angiogenesis, and transcriptional regulation. While a number of Akt substrates are known (such as GSK-3, Bad, and caspase-9) many important substrates await discovery. Akt phosphorylates substrates only at Ser/Thr in a conserved motif characterized by Arg at positions -5 and -3. | |
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