Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit Antibody
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Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit Antibody

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CAT. NO.: AMA-0244

Product Details
Size 100 µL
Reactivity All Species
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with an Akt substrate peptide library.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
Background
An important class of kinases, referred to as Arg-directed kinases or AGC-family kinases, includes cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase (PKG), protein kinase C, Akt, and RSK. These kinases share a substrate specificity characterized by Arg at position -3 relative to the phosphorylated Ser or Thr. Akt plays a central role in mediating critical cellular responses including cell growth and survival, angiogenesis, and transcriptional regulation. While a number of Akt substrates are known (such as GSK-3, Bad, and caspase-9) many important substrates await discovery. Akt phosphorylates substrates only at Ser/Thr in a conserved motif characterized by Arg at positions -5 and -3.

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