CAT. NO.: ABS-046
| Product Details | |
|---|---|
| Alternate Name | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide |
| CAS Number | 391210-10-9 |
| Molecular Formula | C16H14F3IN2O4 |
| Molecular Weight | 482.2 |
| Appearance | Off-white solid |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (20 mg/mL) of EtOH (20 mg/mL) |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O |
| PubChem CID | 9826528 |
| Handling | Protect from air and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells. | |
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