Paxillin (E6R6Z) Rabbit Antibody
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Paxillin (E6R6Z) Rabbit Antibody

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CAT. NO.: AMA-0532

Target Information
UniProt ID P49023
Product Details
Size 100 µL
Reactivity Human, Mouse, Rat
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu63 of human paxillin protein.
Usage
Application WB, IP, IF
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50); Immunofluorescence (1:200-1:800)
MW (Target) 62 kDa
Background
Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

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