Paxillin (D9G12) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0311

Target Information
UniProt ID	P49023

Product Details
Size	100 µL
Reactivity	Human
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys193 of human paxillin protein.

Usage
Application	WB, IP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target)	54 kDa

Background
Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

Background

Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

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