CAT. NO.: ABH-016
| Product Details | |
|---|---|
| Alternate Name | LBH589, LBN-589,NVP-LBH589 |
| CAS Number | 404950-80-7 |
| Molecular Formula | C21H23N3O2 |
| Molecular Weight | 349.43 |
| Appearance | Crystalline solid |
| Purity | ≥99% by HPLC |
| Solubility | DMSO |
| SMILES | CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO |
| PubChem CID | 6918837 |
| Handling | Protect from air and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8 nM. | |
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