CAT. NO.: AMA-0277
| Target Information | |
|---|---|
| UniProt ID | O15350 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala80 of human p73 protein. |
| Usage | |
|---|---|
| Application | WB, IP, IF |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:200); Immunofluorescence (1:200-1:400) |
| MW (Target) | 80 kDa |
| Background | |
|---|---|
| The p53 family member, p73, exists in multiple isoforms/splice variants and can induce apoptosis and cell cycle arrest in response to DNA damage via its activity as a transcription regulator. Upon DNA damage, p73 is phosphorylated at Tyr99 by c-Abl, causing translocation to the nuclear matrix. DNA damage-induced acetylation of p73 at Lys321 by the acetyltransferase p300 has also been reported to enhance transcription of genes including that of p53AIP1. Another report, however, indicates that p300 does not acetylate full-length p73 in vivo. | |
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