CAT. NO.: AMA-0163
| Product Details | |
|---|---|
| Size | 100 μL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val180 of human OXR1 protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 139 kDa |
| Background | |
|---|---|
| Oxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis. Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage. OXR1 also plays a role in cell cycle arrest in response to DNA damage, and is upregulated in cells undergoing senescence. OXR1 is a target of the senolytic agent, piperlongumine, and its analogues. | |
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