OXR1 (E3D2P) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0163

Product Details
Size	100 μL
Reactivity	Human
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val180 of human OXR1 protein.

Usage
Application	WB, IP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target)	139 kDa

Background
Oxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis. Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage. OXR1 also plays a role in cell cycle arrest in response to DNA damage, and is upregulated in cells undergoing senescence. OXR1 is a target of the senolytic agent, piperlongumine, and its analogues.

Background

Oxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis. Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage. OXR1 also plays a role in cell cycle arrest in response to DNA damage, and is upregulated in cells undergoing senescence. OXR1 is a target of the senolytic agent, piperlongumine, and its analogues.

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