NSC-687852
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NSC-687852

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CAT. NO.: ABU-005

Product Details
Alternate Name 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15
CAS Number 1009817-63-3
Molecular Formula C22H17N3O6
Molecular Weight 419.39
Appearance Pale yellow solid
Purity ≥98% by HPLC
Solubility DMSO (35 mg/mL)
SMILES C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
PubChem CID 5351435
Handling Protect from air and light.
Storage Conditions -20°C
Description
Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

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