CAT. NO.: ABU-005
| Product Details | |
|---|---|
| Alternate Name | 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15 |
| CAS Number | 1009817-63-3 |
| Molecular Formula | C22H17N3O6 |
| Molecular Weight | 419.39 |
| Appearance | Pale yellow solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (35 mg/mL) |
| SMILES | C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1 |
| PubChem CID | 5351435 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. | |
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