NSC 146109 hydrochloride

INQUIRY

CAT. NO.: ABU-003

Product Details
Alternate Name	(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
CAS Number	59474-01-0
Molecular Formula	C₁₇H₁₆N₂S.HCl
Molecular Weight	316.85
Appearance	Yellow solid
Purity	≥98% by HPLC
Solubility	DMSO (100 mM) or EtOH (10 mM)
SMILES	CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl
PubChem CID	16759161
Handling	Protect from moisture.
Storage Conditions	-20°C

Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

Description

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.