There has been and continues to be a dramatic shift in the human population towards older ages, necessitating biomedical research aimed at better understanding the basic biology of aging and age-related diseases and facilitating new and improved therapeutic options. As it is impractical to perform the breadth of this research in humans, animal models are necessary to recapitulate the complexity of the aging environment. Non-human primates (NHPs) are more closely related to humans and recapitulate the human aging process and the development of age-related diseases. CD BioSciences is committed to providing innovative longevity solutions that advance scientific discovery. We offer a comprehensive range of NHP aging model customization services to meet the diverse research needs of our clients.
CD BioSciences guides the selection of appropriate primate species based on research objectives, desired physiological similarities to humans, and availability. Our selection process considers factors such as lifespan, cognitive abilities, genetics, and susceptibility to age-related diseases.
| Species | Scientific name | Classification | Advantages |
| Grey mouse lemur | Microcebus murinus | Prosimian | Small body size, short lifespan. |
| Common marmoset | Callithrix jacchus | New World monkey | Small body size, reasonably short lifespan, short generation time, fecundity. |
| Squirrel monkey | Saimiri spp. | New World monkey | Small body size, realistic aging course. |
| Macaques | Macaca sp. | Old World monkey | Well-characterized, closely related to humans, large body size. |
| Vervet monkey | Chlorocebus pygerythrus | Old World monkey | Closely related to humans, large body size. |
| Baboon | Papio hamadryas | Old World monkey | Closely related to humans, large body size. |
| Chimpanzee | Pan troglodytes | Great ape | Closely related to humans, large body size. |
We offer genetic manipulation services to generate transgenic or knock-in/knock-out NHP models with targeted genetic alterations related to aging, such as those associated with longevity, cellular senescence, and age-related pathologies.
Our services support clients in designing and implementing longitudinal aging studies, providing infrastructure for regular health assessments, biomarker monitoring, and assessment of age-related pathology in NHP models.
Studying cognitive decline, memory function, and behavioral changes associated with aging in NHP models requires specialized assessments. CD BioSciences offers customized behavioral and cognitive tests tailored to the specific research aims, to provide a comprehensive evaluation of cognitive aging, including the effects of environmental enrichment, social interaction, and pharmacological interventions on cognitive function.
The rhesus macaque is a well-established model for studying age-related musculoskeletal diseases, such as sarcopenia and osteoarthritis (OA). Using rhesus macaque models, we provide tailored research support to investigate the pathophysiology of musculoskeletal aging and evaluate potential therapeutic interventions for age-related bone and muscle diseases.
The marmoset is valuable for studying aging-related neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). With marmoset models, we offer specialized services for neurodegenerative disease research, including behavioral assessments, neuroimaging, and biomarker analysis, to elucidate the underlying mechanisms of age-related neurodegeneration and develop novel treatment strategies.
CD BioSciences is committed to empowering our clients' research endeavors by offering customized NHP aging models and comprehensive services. If you are interested in our services, please feel free to contact us or make an online inquiry.
Reference
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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