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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Nexturastat A

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CAT. NO.: ABH-013

Product Details
Alternate Name	4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide
CAS Number	1403783-31-2
Molecular Formula	C₁₉H₂₃N₃O₃
Molecular Weight	341.4
Appearance	Off-white solid
Purity	≥98% by HPLC
Solubility	DMSO
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50 = 5.02 ± 0.60 nM). Displays 600-, 1380-, 1330-, 1870-, -2330, -888, -190, -1340, -1510, and -1020-fold selectivities over HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9, HDAC10, and HDAC11, respectively. Nexturastat A also displays antiproliferative effects against melanoma cells.

Description

Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50 = 5.02 ± 0.60 nM). Displays 600-, 1380-, 1330-, 1870-, -2330, -888, -190, -1340, -1510, and -1020-fold selectivities over HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9, HDAC10, and HDAC11, respectively. Nexturastat A also displays antiproliferative effects against melanoma cells.

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.