CAT. NO.: ABM-009
| Product Details | |
|---|---|
| Alternate Name | 1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132 |
| CAS Number | 1144068-46-1 |
| Molecular Formula | C27H33N7O |
| Molecular Weight | 519.6 |
| Appearance | White solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (50 mg/mL) |
| SMILES | CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7 |
| PubChem CID | 25260757 |
| Handling | Protect from light and moisture. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC50 = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. | |
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