mTOR Antibody
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mTOR Antibody

INQUIRY

CAT. NO.: AMA-0108

Target Information
UniProt ID P42345
Product Details
Size 100 μL
Reactivity Human, Monkey, Mouse, Rat
Storage Store at -20°C.
Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser2481 of human mTOR. Antibodies are purified by protein A and peptide affinity chromatography.
Usage
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target) 289 kDa
Background
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.

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