Mitochondrial Modulator Discovery Services

Mitochondria, often referred to as the powerhouses of cells, are critical for energy production, regulation of metabolic pathways, and maintenance of cellular homeostasis. Mitochondrial modulators facilitate cellular energy production and reduce oxidative stress, which are vital for healthy aging. Research has shown that mitochondrial dysfunction is linked to various aging-related diseases, including neurodegenerative diseases, metabolic syndrome, and cardiovascular diseases. By targeting mitochondrial pathways, modulators can enhance mitochondrial biogenesis, improve mitochondrial dynamics, and reduce the accumulation of reactive oxygen species (ROS).

Fig. 1 Summary of the molecular mechanisms involved in the effects of potential mitochondrial modulators. (Naumova N, et al., 2023)

At CD BioSciences, our experts harness advanced research and technology to help clients develop mitochondrial modulators that can potentially reverse or mitigate the effects of aging.

How Do We Help Clients Develop Mitochondrial Modulators?

Target identification and validation

Identification of critical mitochondrial targets is paramount. CD BioSciences utilizes advanced omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to profile mitochondrial changes in experimental models of aging research. Using in vitro and in vivo assays, our experts can offer target validation services to confirm the specificity of identified targets. By focusing on these key regulatory proteins and pathways associated with mitochondrial functions, CD BioSciences aims to develop modulators that can restore mitochondrial function and promote healthy aging.

Discovery of mitochondrial modulators

Once potential targets are identified, we help clients develop novel mitochondrial modulators for anti-aging applications. We also use high-throughput screening (HTS) of drug libraries to identify potential modulators that affect critical mitochondrial functions, such as ATP production, ROS levels, and mitophagy. We help clients develop various mitochondrial modulators, including small molecule inhibitors and activators, as well as gene therapies aimed at modulating mitochondrial functions.

Preclinical evaluation of mitochondrial modulators

Rigorous preclinical studies are essential to evaluate the efficacy and safety of mitochondrial modulators. CD BioSciences conducts comprehensive in vivo studies in aging models to evaluate the impacts of the modulators on aging, such as lifespan, mitochondrial function, muscle strength, and cognitive performance. We employ advanced imaging techniques and biomarker analysis to assess the anti-aging effects of mitochondrial modulators. We also assist in evaluating the safety of modulators to identify potential adverse effects and establish safe dosage ranges.

Analysis of the Mechanism of Action of Mitochondrial Modulators in Aging

Understanding the mechanisms by which mitochondrial modulators exert their effects is crucial for the development of effective anti-aging drugs. CD BioSciences uses various techniques to elucidate these mechanisms.

We employ advanced molecular biology, biochemical, and cellular assays to investigate how modulators affect mitochondrial biogenesis, oxidative phosphorylation, mitophagy, and ROS production. Our experts use fluorescent dyes to visualize mitochondrial morphology and dynamics (fusion and fission events) and to quantify mitochondrial mass in living cells. Our detailed analysis of signaling pathways and downstream effects helps clients unveil the mechanism of actions of mitochondrial modulators and refine future development strategies.

The development of mitochondrial modulators represents a promising frontier for effective anti-aging therapeutics. CD BioSciences aims to help clients develop novel mitochondrial modulators that improve lifespan by focusing on the intricate mechanisms of mitochondrial function. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Naumova N, et al. Mitochondrial modulators. Anti-Aging Pharmacology, 2023, 193-226.