The free radical theory of aging is several decades old. As mitochondria are the principal source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. With aging, mitochondria are more vulnerable to morphological changes. These changes result in reduced function due to oxygen radical damage, which eventually causes the aging of the organism.
Fig. 1 Mitochondrial dysfunction during aging and age-related disorders. (Srivastava S, 2017)
Mitochondrial dysfunction is a key hallmark of aging and is associated with a wide range of age-related diseases. At CD BioSciences, we provide a wide range of analysis services dedicated to studying mitochondrial dysfunction in aging.
Our analysis services are focused on examining the impact of reactive oxygen species (ROS) on mitochondrial dysfunction during the aging process. We utilize techniques, including fluorescence-based assays and mass spectrometry, to quantify ROS levels and evaluate oxidative damage to mitochondria. By comprehending the influence of ROS on mitochondrial function, we can gain an understanding of the underlying mechanisms of mitochondrial dysfunction related to aging.
Our core service involves analyzing the connection between mitochondria, aging, and ROS levels. This relationship is closely intertwined with redox stress signaling thresholds (RST) and mitochondrial depolarization. Our services are adaptable to various animal models, including nematodes, mice, naked mole rats, and bats.
Our company offers analysis services to evaluate disorders associated with mitochondrial energy metabolism in aging. We employ high-resolution respirometry and metabolomics profiling techniques to assess mitochondrial respiration, adenosine triphosphate (ATP) production, and metabolic changes. By clarifying changes in mitochondrial energy metabolism, we can identify potential targets for interventions to mitigate age-related mitochondrial dysfunction.
Our services are crucial in aging-related research as we can first identify and validate biomarkers that are relevant to disorders of mitochondrial energy metabolism during the aging process. Secondly, we can assess mitochondrial lifespan to gain a better understanding of the aging process.
CD BioSciences provides analysis services to investigate the quality control of mitochondria during the aging process. Our range of services includes assessing mitochondrial dynamics, mitophagy, proteostasis, and mitochondrial DNA (mtDNA) integrity.
By utilizing imaging techniques, proteomic strategies, and molecular biology assays, we can investigate variations in mitochondrial quality control and their impact on mitochondrial dysfunction over time. Furthermore, we expose the internal mechanisms that influence mitochondrial quality control during senescence, encompassing both mitophagy and the mitochondria-derived vesicle pathway.
Mitochondrial dysfunction is a crucial factor in the aging process and age-related diseases. CD BioSciences, equipped with substantial biological analysis experience and knowledge, provides comprehensive analysis services for the study of mitochondrial dysfunction in aging. If you are interested in our services or have any questions, please feel free to contact us to discuss how we can be involved in your research program.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a contract research organization focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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