CAT. NO.: AMA-0218
Product Details | |
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Size | 100 μL |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Source/Isotype | Rabbit IgG |
Storage | Store at -20°C. |
Purification | Affinity purified |
Usage | |
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Application | WB |
Product Usage Information Dilution | Western Blotting (1:500-1000) |
Background | |
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MAP kinase kinase 1 (Mek1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway. |
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