MDM2 (E3G5I) Rabbit Antibody
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MDM2 (E3G5I) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0540

Target Information
UniProt ID Q00987
Product Details
Size 100 µL
Reactivity Human, Mouse, Rat
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human MDM2 protein. This antibody recognizes an epitope surrounding Val280 of human MDM2 protein.
Usage
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target) 90 kDa
Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.

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