MDM2 (D1V2Z) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0262

Target Information
UniProt ID	Q00987

Product Details
Size	100 µL
Reactivity	Human
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val280 of human MDM2 protein.

Usage
Application	WB, IP, IF
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:200-1:800)
MW (Target)	90 kDa

Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.

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