CAT. NO.: AMA-0262
| Target Information | |
|---|---|
| UniProt ID | Q00987 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val280 of human MDM2 protein. |
| Usage | |
|---|---|
| Application | WB, IP, IF |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:200-1:800) |
| MW (Target) | 90 kDa |
| Background | |
|---|---|
| MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. | |
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