MDM2 (D1V2Z) Rabbit Antibody (Biotinylated)
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MDM2 (D1V2Z) Rabbit Antibody (Biotinylated)

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CAT. NO.: AMA-0287

Target Information
UniProt ID Q00987
Product Details
Size 100 µL
Reactivity Human
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val280 of human MDM2 protein.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 90 kDa
Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.

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