LKB1 (D60C5) Rabbit Antibody
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LKB1 (D60C5) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0086

Target Information
UniProt ID Q15831
Product Details
Size 100 μL
Reactivity Human, Monkey, Mouse, Rat
Host Rabbit
Source/Isotype Rabbit IgG
Storage Store at -20°C.
Purification Monoclonal antibody is produced by immunizing animals with an LKB1 partial fusion protein.
Usage
Application WB
Product Usage Information Dilution Western Blotting (1:1000)
MW (Target) 54 kDa
Background
LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases. A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363.Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands, and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

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