CAT. NO.: AMA-0679
| Target Information | |
|---|---|
| UniProt ID | O43504 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu55 of human LAMTOR5/HBXIP protein. |
| Usage | |
|---|---|
| Application | WB, IP, IHC |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50); Immunohistochemistry (1:800) |
| MW (Target) | 10.5 kDa |
| Background | |
|---|---|
| Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 (LAMTOR5) is an essential component of the ragulator protein complex that is encoded by the HBXIP gene The ragulator complex also includes LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, and LAMTOR4/C7orf59 Research studies demonstrate that the ragulator complex localizes to the lysosomal membrane and is essential for the lysosomal localization of Rag GTPases and mTORC1 as well as the subsequent activation of mTORC1 in response to amino acid signaling Additional research studies indicate that HBXIP regulates hepatitis B virus x (HBx) protein activity and is a transcription coactivator involved in the proliferation and migration of breast cancer cells. | |
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