LAMTOR2/ROBLD3 (D7C10) Rabbit Antibody

INQUIRY

CAT. NO.: AMA-0668

Target Information
UniProt ID	Q9Y2Q5

Product Details
Size	100 µL
Reactivity	Human, Mouse, Rat, Monkey
Host	Rabbit
Source/Isotype	Rabbit IgG
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu31 of human LAMTOR2/ROBLD3 protein.

Usage
Application	WB, IP
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:50)
MW (Target)	14 kDa

Background
mTORC1 kinase complex is a critical component in the regulation of cell growth Its activity is modulated by energy levels, growth factors, and amino acids The four related GTPases, RagA, RagB, RagC, and RagD, have been shown to interact with raptor in mTORC1 These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals A protein complex consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, and LAMTOR3/MAPKSP1 has been identified to interact with and recruit the four Rag GTPases to the surface of lysosomes.

Background

mTORC1 kinase complex is a critical component in the regulation of cell growth Its activity is modulated by energy levels, growth factors, and amino acids The four related GTPases, RagA, RagB, RagC, and RagD, have been shown to interact with raptor in mTORC1 These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals A protein complex consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, and LAMTOR3/MAPKSP1 has been identified to interact with and recruit the four Rag GTPases to the surface of lysosomes.

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