LAMP-1 Antibody

INQUIRY

CAT. NO.: AMA-0215

Product Details
Size	100 µg
Reactivity	Human, Mouse, Rat
Host	Rabbit
Source/Isotype	Rabbit IgG1
Storage	Store at -20°C.
Purification	Affinity chromatography purified via peptide column.

Usage
Application	WB, IHC, ELISA
Product Usage Information Dilution	Western Blotting (1-2 μg/mL); Immunofluorescence (20 μg/mL)

Background
Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thoμght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, sμggesting that each protein possesses some unique and necessary functions.

Background

Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thoμght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, sμggesting that each protein possesses some unique and necessary functions.

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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.