CAT. NO.: ABS-034
| Product Details | |
|---|---|
| Alternate Name | 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
| CAS Number | 142273-20-9 |
| Molecular Formula | C16H11BrN2O |
| Molecular Weight | 327.18 |
| Appearance | Tan solid |
| Purity | ≥98% |
| Solubility | DMSO (>25 mg/mL) |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
| PubChem CID | 3820 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680nM) , CDK5 (IC50 = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC50 = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway. | |
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