ITSA-1

INQUIRY

CAT. NO.: ABH-010

Product Details
Alternate Name	N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide, ITSA1
CAS Number	200626-61-5
Molecular Formula	C₁₃H₇Cl₂N₃O
Molecular Weight	292.12
Appearance	White solid
Purity	≥98% by TLC
Solubility	DMSO (25 mg/mL)
SMILES	C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
PubChem CID	771910
Handling	Protect from air and light.
Storage Conditions	-20°C

Description
Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis.

Description

Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis.

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