CAT. NO.: AMA-0004
| Target Information | |
|---|---|
| UniProt ID | Q9Y4H2 |
| Product Details | |
|---|---|
| Size | 100 μL |
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1326 of human IRS-2. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50) |
| MW (Target) | 185 kDa |
| Background | |
|---|---|
| Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase. In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades. IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults. | |
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