Hypertension Model Customization Services for Aging Research

Hypertension, or high blood pressure, is a disease that poses significant health risks. Its prevalence is particularly high in older adults. Various factors, including genetics, diet, physical activity, stress, and aging can influence it. Experimental models have become indispensable tools for understanding the pathogenesis of hypertension and developing therapeutic interventions.

With decades of experience, CD BioSciences has established itself as a trusted partner for researchers in the field of aging. One area in which we have particularly excelled is the development of customized hypertension models tailored specifically for aging research.

Custom Animal Models of Hypertension for Aging Research

Nongenetic models of hypertension

CD BioSciences has developed expertise in nongenetic approaches to inducing hypertension in animals. These models, which involve dietary modifications, surgical interventions, or pharmacological manipulations, allow our clients to investigate the impact of environmental and lifestyle factors on the development and progression of age-related hypertension. The following is a list of some of these models:

• Deoxycorticosterone acetate (DOCA)-salt models
• Chronic Ang II hypertension models
• Animal models of obesity-induced hypertension
• 2A, 2-kidney 1-clip Goldblatt hypertension models
• Hypertensive 5/6 renal ablation models

Genetic rat models of hypertension

From spontaneously hypertensive rats (SHR) to Dahl salt-sensitive (DSS) rats, our model is specifically designed to facilitate research into the mechanisms of hypertension and its impact on aging. We also offer the fawn-hooded hypertensive (FHH) rat, the Milan hypertensive strain, the Lyon hypertensive rat, and the Sabra hypertensive rat models that exhibit hypertension.

Transgenic models of hypertension

We help clients customize transgenic rodent models that replicate hypertension, such as the TGR(mRen2)27 transgenic rat model of hypertension. Our experts work closely with our clients to identify the optimal approach for their research objectives.

Large genetic animal models of hypertension

While rodent models have been the traditional focus of aging research, CD BioSciences also offers customized large genetic animal models of hypertension. Our model customization services support swine, nonhuman primates, and sheep species, helping clients study the cardiovascular and renal consequences of age-related hypertension.

Applications of Animal Models of Hypertension in Aging Research

• Elucidation of age-related changes. Our animal models allow clients to delve deep into the underlying mechanisms that drive this age-related phenomenon. From vascular stiffening and endothelial dysfunction to changes in the renin-angiotensin-aldosterone system, the customized models we help clients develop enable the detailed investigation of the molecular changes that contribute to the development and progression of hypertension over time.
• Evaluation of therapeutic interventions. Whether investigating the efficacy of antihypertensive drugs, testing the potential of lifestyle modifications, or exploring innovative regenerative approaches, our customized models can provide a robust platform for evaluating the safety and efficacy of interventions.

At CD BioSciences, we take pride in our ability to provide tailored solutions that meet the evolving needs of aging research. Our team of scientists collaborates closely with our clients to design, develop, and validate optimal hypertension models. If you are interested in our services, please feel free to contact us or make an online inquiry.

Reference

1. Lerman LO, et al. Animal Models of Hypertension: A Scientific Statement From the American Heart Association. Hypertension, 2019, 73 (6): e87-e120.