Human Telomere length Regulation Protein TEL2 Homolog (TELO2) ELISA Kit

INQUIRY

CAT. NO.: TK106

General Info
Size	48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells
Product Overview	This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) Kit designed for the assessment of the TEL2, telomere maintenance 2, homolog (TELO2) ELISA Kit target analytes within biological samples. The concentration gradients of the Kit standards or positive controls render a theoretical Kit detection range in biological research samples containing TELO2. The ELISA analytical biochemical technique of the Kit is based on TELO2 antibody-TELO2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TELO2 antigen targets in samples. It's important to note that this ELISA Kit is specifically tailored for detecting native, not recombinant TELO2.
Storage Conditions	Store all reagents at 2-8°C
Notes	Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the TELO2 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation.
Reactivity	Human
Shipping Conditions	Dry Ice

Product Details
Samples	Undiluted Body Fluids, Tissue Homogenates, Secretions

Target Info
Molecular Weight	91,747 Da
NCBI Accession	NP_057195.2
NCBI GenBank Nucleotide	NM_016111.3
NCBI GeneID	9894
NCBI Official Full Name	telomere length regulation protein TEL2 homolog
NCBI Official Symbol	TELO2
NCBI Official Synonym Full Names	telomere maintenance 2
NCBI Official Synonym Symbols	CLK2, TEL2
NCBI Protein Information	telomere length regulation protein TEL2 homolog, protein clk-2 homolog, TEL2, telomere maintenance 2, homolog
OMIM	611140
UniProt Entry Name	TELO2_HUMAN
UniProt Gene Name	TELO2
UniProt Protein Name	Telomere length regulation protein TEL2 homolog
UniProt Synonym Gene Names	KIAA0683, hCLK2
UniProt Synonym Protein Names	Protein clk-2 homolog, hCLK2
UniProt Primary Accession	Q9Y4R8
UniProt Secondary Accession	O75168, Q7LDV4, Q9BR21, D3DU73
Protein Family	Telomere length regulation protein
NCBI Summary	This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]
UniProt Comments	TELO2: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Belongs to the TEL2 family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 16p13.3Cellular Component: chromosome, telomeric region; membrane; cytoplasm; TORC2 complex; intracellular; nucleusMolecular protein binding; protein complex binding; protein complex scaffoldBiological Process: regulation of TOR signaling pathway

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