Human Regulator of Telomere Elongation Helicase 1 (RTEL1) ELISA Kit

INQUIRY

CAT. NO.: TK104

General Info
Size	48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells
Product Overview	This quantitative sandwich ELISA Kit is only for in vitro research use only! This Kit is intended to be used for determination the level of RTEL1 in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This Kit is NOT suitable for assaying non-biological sources of substances.
Storage Conditions	Store all reagents at 2-8°C
Notes	Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the RTEL1 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation.
Reactivity	Human
Specificity	No significant cross-reactivity or interference between this analyte and analogues is observed.
Shipping Conditions	Dry Ice

Product Details
Assay Type	Quantitative Sandwich
Samples	Body Fluids, Tissue Homogenates, Secretions, Feces Samples
Detection Range	0.25-8 ng/mL
Sensitivity	0.1 ng/mL
Inter-assay CV	CV<15%
Intra-assay CV	CV<15%
Detection Wavelength	450 nm

Target Info
Molecular Weight	133,683 Da
NCBI Accession	NP_001269938.1
NCBI GenBank Nucleotide	NM_001283009.1
NCBI GeneID	51750
NCBI Official Full Name	regulator of telomere elongation helicase 1 isoform 3
NCBI Official Symbol	RTEL1
NCBI Official Synonym Full Names	regulator of telomere elongation helicase 1
NCBI Official Synonym Symbols	NHL, RTEL, DKCA4, DKCB5, C20orf41
NCBI Protein Information	regulator of telomere elongation helicase 1, regulator of telomere length
OMIM	615190
UniProt Entry Name	RTEL1_HUMAN
UniProt Gene Name	RTEL1
UniProt Protein Name	Regulator of telomere elongation helicase 1
UniProt Synonym Gene Names	C20orf41, KIAA1088, NHL
UniProt Synonym Protein Names	Novel helicase-like
UniProt Primary Accession	Q9NZ71
UniProt Secondary Accession	Q5JTV3, Q5JTV4, Q9BW37, Q9H402, A2A397, A2A398, B4DRM5, B4DYM3, B4E3N6, E1P5J4, E1P5J5
Protein Family	Regulator of telomere elongation helicase
NCBI Summary	This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
UniProt Comments	RTEL1: ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function. Belongs to the helicase family. RAD3/XPD subfamily. 8 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.12; DNA repair, damage; HelicaseChromosomal Location of Human Ortholog: 20q13.3Cellular Component: nucleusMolecular ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP bindingBiological Process: DNA repair; telomere maintenance; DNA duplex unwindingDisease: Dyskeratosis Congenita, Autosomal Recessive, 5; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 3

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