CAT. NO.: TK104
| General Info | |
|---|---|
| Size | 48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells |
| Product Overview | This quantitative sandwich ELISA Kit is only for in vitro research use only! This Kit is intended to be used for determination the level of RTEL1 in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This Kit is NOT suitable for assaying non-biological sources of substances. |
| Storage Conditions | Store all reagents at 2-8°C |
| Notes | Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the RTEL1 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation. |
| Reactivity | Human |
| Specificity | No significant cross-reactivity or interference between this analyte and analogues is observed. |
| Shipping Conditions | Dry Ice |
| Product Details | |
|---|---|
| Assay Type | Quantitative Sandwich |
| Samples | Body Fluids, Tissue Homogenates, Secretions, Feces Samples |
| Detection Range | 0.25-8 ng/mL |
| Sensitivity | 0.1 ng/mL |
| Inter-assay CV | CV<15% |
| Intra-assay CV | CV<15% |
| Detection Wavelength | 450 nm |
| Target Info | |
|---|---|
| Molecular Weight | 133,683 Da |
| NCBI Accession | NP_001269938.1 |
| NCBI GenBank Nucleotide | NM_001283009.1 |
| NCBI GeneID | 51750 |
| NCBI Official Full Name | regulator of telomere elongation helicase 1 isoform 3 |
| NCBI Official Symbol | RTEL1 |
| NCBI Official Synonym Full Names | regulator of telomere elongation helicase 1 |
| NCBI Official Synonym Symbols | NHL, RTEL, DKCA4, DKCB5, C20orf41 |
| NCBI Protein Information | regulator of telomere elongation helicase 1, regulator of telomere length |
| OMIM | 615190 |
| UniProt Entry Name | RTEL1_HUMAN |
| UniProt Gene Name | RTEL1 |
| UniProt Protein Name | Regulator of telomere elongation helicase 1 |
| UniProt Synonym Gene Names | C20orf41, KIAA1088, NHL |
| UniProt Synonym Protein Names | Novel helicase-like |
| UniProt Primary Accession | Q9NZ71 |
| UniProt Secondary Accession | Q5JTV3, Q5JTV4, Q9BW37, Q9H402, A2A397, A2A398, B4DRM5, B4DYM3, B4E3N6, E1P5J4, E1P5J5 |
| Protein Family | Regulator of telomere elongation helicase |
| NCBI Summary | This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] |
| UniProt Comments | RTEL1: ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function. Belongs to the helicase family. RAD3/XPD subfamily. 8 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.12; DNA repair, damage; HelicaseChromosomal Location of Human Ortholog: 20q13.3Cellular Component: nucleusMolecular ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP bindingBiological Process: DNA repair; telomere maintenance; DNA duplex unwindingDisease: Dyskeratosis Congenita, Autosomal Recessive, 5; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 3 |
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