CAT. NO.: APE-039
| Product Details | |
|---|---|
| Size | 50 μg |
| Alternate Name | UBE1, UBA1, POC20, A1S9T, A1ST, AMCX1, GXP1, SMAX2 |
| Gene Symbol | UBA1 |
| Gene ID | 7317 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | In 50 mM Tris (pH 8.0), 100 mM NaCl and 10% glycerol. |
| Molecular Weight | 118 kDa |
| Purity by SDS-PAGE | ≥95% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Description | |
|---|---|
| UBE1, the ubiquitin activating enzyme, is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate. | |
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