Human recombinant Ubiquitin Activating Enzyme E1

INQUIRY

CAT. NO.: APE-039

Product Details
Size	50 μg
Alternate Name	UBE1, UBA1, POC20, A1S9T, A1ST, AMCX1, GXP1, SMAX2
Gene Symbol	UBA1
Gene ID	7317
Source	E. coli
Appearance	Liquid
Physical Form Description	In 50 mM Tris (pH 8.0), 100 mM NaCl and 10% glycerol.
Molecular Weight	118 kDa
Purity by SDS-PAGE	≥95%
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-80°C

Description
UBE1, the ubiquitin activating enzyme, is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate.

Description

UBE1, the ubiquitin activating enzyme, is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate.

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.