Human ELOVL2 Promoter and Global DNA Dual Methylation Quantification qPCR Assay Kit

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CAT. NO.: SMT001

General Info
Size	100 reactions
Product Overview	DNA methylation at CpG islands in promoters regulates gene expression. It is a dynamic epigenetic process affected by various genetic and environmental factors. Numerous diseases including cancer have been linked to aberrant global changes in genomic DNA methylation. It is generally thought that global genomic DNA methylation level can be represented by the methylation level at repetitive elements. One example of this includes the repetitive Long Interspersed Nuclear Element-1 (LINE-1), which compromises 17-18% of the human genome and is usually heavily methylated in most normal primary cells. Furthermore, the CpG island methylation level at human ELOVL2 gene promoter has been well-associated with chronological age in various populations, cell types, and tissues. ELOVL2 promoter methylation level is therefore a potential marker for human chronological age.

General Info

Size

100 reactions

Product Overview

DNA methylation at CpG islands in promoters regulates gene expression. It is a dynamic epigenetic process affected by various genetic and environmental factors. Numerous diseases including cancer have been linked to aberrant global changes in genomic DNA methylation. It is generally thought that global genomic DNA methylation level can be represented by the methylation level at repetitive elements. One example of this includes the repetitive Long Interspersed Nuclear Element-1 (LINE-1), which compromises 17-18% of the human genome and is usually heavily methylated in most normal primary cells. Furthermore, the CpG island methylation level at human ELOVL2 gene promoter has been well-associated with chronological age in various populations, cell types, and tissues. ELOVL2 promoter methylation level is therefore a potential marker for human chronological age.

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