Heart failure (HF) is a complex clinical syndrome characterized by the inability of the heart to pump sufficient blood to meet the body's metabolic needs. Aging is not only a chronological process but also involves a gradual decline in the physiological function of various organs, including the heart. The aging heart undergoes structural and functional changes that can predispose individuals to heart failure. Experimental models, particularly rats, have been instrumental in advancing our understanding of heart failure and developing pharmacological therapies.
Fig. 1 Surgical techniques and limitations for some experimental rat models of heart failure. (Farag A, et al., 2023)
With decades of experience, CD BioSciences is devoted to providing heart failure model customization services to support aging research. Our team of seasoned experts understands the intricacies of heart failure pathophysiology and the unique challenges faced when studying this disease in aging.
We help clients develop cell models of heart failure using cardiomyocytes derived from human or animal sources, including induced pluripotent stem cells (iPSCs). Our services assist clients in studying the intricate cellular and molecular mechanisms underlying the pathogenesis of heart failure in the elderly.
Cardiac fibroblasts play a crucial role in the development and progression of heart failure. Our experts can help clients customize cell models using cardiac fibroblasts to investigate the pathogenesis of heart failure.
Rat models have long been a staple in heart failure research due to their physiological similarities to humans. We offer customized rat heart failure models that can be tailored to simulate the effects of aging. We incorporate pressure overload-induced hypertrophy, myocardial infarction, or genetic modifications in rat models to recapitulate the hallmarks of age-related heart failure. By adjusting parameters such as the age of the animals and the duration of the study, our experts can help clients unravel the intricate mechanisms underlying the progression of heart failure in the aging process.
We also use mouse models of heart failure to help clients investigate the molecular and genetic alterations underlying heart failure. We offer transgenic mouse models of heart failure through genetic manipulations. Leveraging our customized models, clients can gain a clear understanding of the complex interplay between aging, genetic factors, and the development of heart failure.
We offer customized large animal models of heart failure, such as pigs, dogs, or rabbits. These models resemble humans in heart architecture, heart rate, oxygen consumption, contractility, protein expression, and even stem cell populations. We help clients develop balloon occlusion of the left anterior descending coronary artery models in pigs, coronary artery occlusion, and pressure overload of the left ventricle models in rabbits. Using genetic modification, our experts can design these models to mimic aging hallmarks with heart failure characteristics.
CD BioSciences is committed to offering our clients heart failure model customization services to support their aging research. Our customized heart failure models are essential tools for preclinical studies. If you are interested in our services, please feel free to contact us or make an online inquiry.
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All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
CD BioScience is a research service provider focused on aging research, specializing in providing research on aging mechanisms, preclinical drug discovery and development, and the development of healthcare and skincare products.
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