CAT. NO.: SAT-053
| General Info | |
|---|---|
| Size | 25 tests |
| Product Overview | Histone deacetylases (HDACs) play a central role in controlling cell cycle regulation, cell differentiation, and tissue development. HDAC1 is ubiquitously expressed and plays a role in cellular senescence, cardiomyocyte differentiation and hypertrophy, aging of the liver, myelination, and adult neurogenesis to name a few functions. The HDAC1 IP & Activity Assay Kit provides an antibody-based method to specifically immunoprecipitate the HDAC1 complex from cells & tissues and to measure HDAC1 activity fluorometrically. HDAC1 is immunoprecipitated from cell, nuclear or tissue extract(s) using HDAC1 antibody followed by capturing the complex on protein-A/G beads. The immunoprecipitated complex is incubated with the HDAC substrate. Only the deacetylated substrate is cleaved by the Developer to produce a fluorophore, which can be easily analyzed using a fluorescence plate reader. |
| Notes | • Immunoprecipitation of HDAC1 complex from cell, nuclear, or tissue extract(s). • Measurement of HDAC1 activity of immunoprecipitated complex/purified enzyme. • Screening for activators or inhibitors of HDAC1. |
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