CAT. NO.: ABH-009
Product Details | |
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Alternate Name | 7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide; 7-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide |
CAS Number | 1012054-55-5 |
Molecular Formula | C22H24ClFN4O4 |
Molecular Weight | 462.9 |
Appearance | Solid |
Purity | 95% |
Solubility | Soluble in DMSO |
SMILES | O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC |
Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
Storage Conditions | -20°C |
Description | |
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HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC50 values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC50 values of 0.93 μM, 0.71 μM, 0.90 μM respectively. |
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