HDAC, EGFR & HER2 inhibitor
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HDAC, EGFR & HER2 inhibitor

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CAT. NO.: ABH-009

Product Details
Alternate Name 7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide; 7-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
CAS Number 1012054-55-5
Molecular Formula C22H24ClFN4O4
Molecular Weight 462.9
Appearance Solid
Purity 95%
Solubility Soluble in DMSO
SMILES O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Description
HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC50 values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits the growth of different cell lines such as HCC827, H358, H460 with IC50 values of 0.93 μM, 0.71 μM, 0.90 μM respectively.

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