CAT. NO.: ABM-007
| Product Details | |
|---|---|
| Alternate Name | 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide; Omipalisib |
| CAS Number | 1086062-66-9 |
| Molecular Formula | C25H17F2N5O3S |
| Molecular Weight | 505.5 |
| Appearance | Off-white solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (5 mg/mL) |
| SMILES | COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F |
| PubChem CID | 25167777 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). in vivo, GSK2126458 displays anti-tumor activity in both pharmacodynamic and tumor growth efficacy models. | |
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