CAT. NO.: AMA-0512
| Target Information | |
|---|---|
| UniProt ID | Q9UNA1 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys261 of human GRAF1 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB |
| Product Usage Information Dilution | Western Blotting (1:1000) |
| MW (Target) | 92 kDa |
| Background | |
|---|---|
| GTPase Regulator Associated with Focal Adhesion Kinase-1 (GRAF1), is a GTPase-activating protein for the small G proteins RhoA and Cdc42 It is composed of an N-terminal BAR domain, a PH domain, a RhoGAP domain, a proline-rich domain, and a C-terminal SH3 domain. GRAF1 contributes to the clathrin-independent carriers/GPI-enriched early endosomal compartments (CLIC/GEEC) pathway, and was the first specific protein component of this endocytic pathway to be discovered GRAF1 was identified as an important protein necessary for adeno-associated virus 2 infection In addition, research studies have linked GRAF1 to mental retardation skeletal muscle differentiation and myeloid leukemia. | |
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