Goat CST Complex Subunit (CTC1) ELISA Kit

INQUIRY

CAT. NO.: TK091

General Info
Size	48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells
Product Overview	This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) Kit designed for the assessment of the CST complex subunit CTC1 (C17orf68) ELISA Kit target analytes within biological samples. The concentration gradients of the Kit standards or positive controls render a theoretical Kit detection range in biological research samples containing C17orf68. The ELISA analytical biochemical technique of the Kit is based on C17orf68 antibody-C17orf68 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C17orf68 antigen targets in samples. It's important to note that this ELISA Kit is specifically tailored for detecting native, not recombinant C17orf68.
Storage Conditions	Store all reagents at 2-8°C
Notes	Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the CTC1 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation.
Reactivity	Goat
Shipping Conditions	Dry Ice

Product Details
Samples	Serum, Plasma, Cell Culture Supernatants, Body Fluid, Tissue Homogenate
Sample Preparation	We recommend preliminary experimentation using undiluted samples or dilutions at ratios of 1:2 or 1:4. Please refrain from exceeding a 1:10 dilution, as it surpasses the prescribed dilution threshold for this kit.

Target Info
Molecular Weight	114,142 Da
NCBI Accession	NP_079375.3
NCBI GenBank Nucleotide	NM_025099.5
NCBI GeneID	80169
NCBI Official Full Name	CST complex subunit CTC1
NCBI Official Symbol	CTC1
NCBI Official Synonym Full Names	CTS telomere maintenance complex component 1
NCBI Official Synonym Symbols	CRMCC, AAF132, AAF-132, C17orf68, tmp494178
NCBI Protein Information	CST complex subunit CTC1, alpha accessory factor 132, HBV DNAPTP1-transactivated protein B, conserved telomere capping protein 1
OMIM	613129
UniProt Entry Name	CTC1_HUMAN
UniProt Gene Name	CTC1
UniProt Protein Name	CST complex subunit CTC1
UniProt Synonym Gene Names	C17orf68
UniProt Synonym Protein Names	Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B
UniProt Primary Accession	Q2NKJ3
UniProt Secondary Accession	Q1PCD1, Q2TBE3, Q8N3S6, Q9H6L0, B3KR66, C9JEX5
NCBI Summary	This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
UniProt Comments	CTC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Defects in CTC1 are the cause of cerebroretinal microangiopathy with calcifications and cysts (CRMCC). An autosomal recessive pleiomorphic disorder characterized primarily by intracranial calcifications, leukodystrophy, and brain cysts. Affected individuals manifest a phenotype consistent with Coats plus syndrome or Labrune syndrome. Coats plus syndrome patients have retinal telangiectasia and exudates as well as extraneurologic manifestations, including osteopenia with poor bone healing and a high risk of gastrointestinal bleeding and portal hypertension caused by vasculature ectasias in the stomach, small intestine, and liver. Some individuals with Coats syndrome also have hair, skin, and nail changes, as well as anemia. Patients with Labrune syndrome do not have extraneurologic manifestations. Belongs to the CTC1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA replication; DNA-bindingChromosomal Location of Human Ortholog: 17p13.1Cellular Component: nuclear chromosome, telomeric region; nucleusMolecular protein binding; single-stranded DNA bindingBiological Process: bone marrow development; spleen development; positive regulation of fibroblast proliferation; thymus development; multicellular organism growth; regulation of G2/M transition of mitotic cell cycle; response to DNA damage stimulus; telomere maintenance; positive regulation of DNA replicationDisease: Cerebroretinal Microangiopathy With Calcifications And Cysts

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