CAT. NO.: APE-023
| Product Details | |
|---|---|
| Alternate Name | Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2 |
| Gene Symbol | HAGH |
| Gene ID | 3029 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 30% glycerol, 50 mM Tris pH 7.4 and 150 mM NaCl |
| Molecular Weight | 32.4 kDa |
| Purity by SDS-PAGE | ≥90% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis. | |
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