Glyoxalase II (Glx II), human recombinant

INQUIRY

CAT. NO.: APE-023

Product Details
Alternate Name	Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2
Gene Symbol	HAGH
Gene ID	3029
Source	E. coli
Appearance	Liquid
Physical Form Description	30% glycerol, 50 mM Tris pH 7.4 and 150 mM NaCl
Molecular Weight	32.4 kDa
Purity by SDS-PAGE	≥90%
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-20°C

Description
The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.

Description

The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.

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