CAT. NO.: ABS-018
| Product Details | |
|---|---|
| Alternate Name | 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis(N,N-dimethyl-benzenamine); NSC 136476 |
| CAS Number | 500579-04-4 |
| Molecular Formula | C27H35N5 |
| Molecular Weight | 429.6 |
| Appearance | White to off-white solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>2 mg/mL) |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
| PubChem CID | 421610 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC50 = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice. | |
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