CAT. NO.: ABS-017
| Product Details | |
|---|---|
| Alternate Name | 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503 |
| CAS Number | 64048-12-0 |
| Molecular Formula | C24H16N4S |
| Molecular Weight | 392.48 |
| Appearance | Yellow solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (25 mM) or Ethanol (25 mM) |
| SMILES | C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5 |
| PubChem CID | 253078 |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo. | |
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