CAT. NO.: ABM-005
| Product Details | |
|---|---|
| Alternate Name | 2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile; ATRi |
| CAS Number | 1345675-02-6 |
| Molecular Formula | C30H22N4O2 |
| Molecular Weight | 470.52 |
| Appearance | White solid |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (10 mg/mL) |
| SMILES | CC(C)(C#N)C(C=C1)=CC=C1N(C2=C(CO3)C=NC(C2=C4)=CC=C4C5=CC6=CC=CC=C6N=C5)C3=O |
| Handling | Protect from air and light. |
| Storage Conditions | -20°C |
| Description | |
|---|---|
| A potent ATR (ATM and Rad3-related) inhibitor (IC50 = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC50's of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea. | |
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