Equine Telomere Repeat Binding Factor1 (TRF1) ELISA Kit

INQUIRY

CAT. NO.: TK088

General Info
Size	48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells
Product Overview	This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) kit designed for the assessment of the telomere repeat binding factor1 (TRF1) ELISA kit target analytes within biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TRF1. The ELISA analytical biochemical technique of the kit is based on TRF1 antibody-TRF1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRF1 antigen targets in samples. It's important to note that this ELISA kit is specifically tailored for detecting native, not recombinant TRF1.
Storage Conditions	Store all reagents at 2-8°C
Notes	Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the TRF1 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation.
Reactivity	Horse
Shipping Conditions	Dry Ice

Product Details
Samples	Undiluted Body Fluids, Tissue Homogenates, Secretions

Target Info
Molecular Weight	50,246 Da
NCBI Accession	NP_059523.2
NCBI GenBank Nucleotide	NM_017489.2
NCBI GeneID	7013
NCBI Official Full Name	telomeric repeat-binding factor 1 isoform 1
NCBI Official Symbol	TERF1
NCBI Official Synonym Full Names	telomeric repeat binding factor (NIMA-interacting) 1
NCBI Official Synonym Symbols	TRF, PIN2, TRF1, TRBF1, t-TRF1, hTRF1-AS
NCBI Protein Information	telomeric repeat-binding factor 1, NIMA-interacting protein 2, telomeric protein Pin2/TRF1, TTAGGG repeat-binding factor 1
OMIM	600951
UniProt Entry Name	TERF1_HUMAN
UniProt Gene Name	TERF1
UniProt Protein Name	Telomeric repeat-binding factor 1
UniProt Synonym Gene Names	PIN2, TRBF1, TRF, TRF1
UniProt Synonym Protein Names	NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1
UniProt Primary Accession	P54274
UniProt Secondary Accession	Q15553, Q8NHT6, Q93029, A7XP29
Protein Family	Telomeric DNA-binding factor
NCBI Summary	This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
UniProt Comments	TRF1: a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8q21.11Cellular Component: nucleoplasm; chromosome, telomeric region; nuclear telomere cap complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; spindle; nucleusMolecular protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; microtubule binding; telomeric DNA binding; double-stranded telomeric DNA binding; chromatin binding; DNA bending activityBiological Process: response to drug; mitosis; positive regulation of mitosis; negative regulation of telomere maintenance via semi-conservative replication; positive regulation of apoptosis; positive regulation of microtubule polymerization; telomere maintenance via telomerase; positive regulation of mitotic cell cycle; negative regulation of telomerase activity; negative regulation of DNA replication; cell division; telomeric loop formation; mitotic cell cycle spindle assembly checkpoint; G2/M transition of mitotic cell cycle; age-dependent telomere shortening; telomere maintenance; negative regulation of telomere maintenance via telomerase; protein homooligomerization

Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our products, please contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.