eIF6 Antibody

INQUIRY

CAT. NO.: AMA-0506

Target Information
UniProt ID	P56537

Product Details
Size	100 µL
Reactivity	Human, Mouse, Rat
Storage	Store at -20°C. Do not aliquot the antibody.
Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human eIF6. Antibodies are purified by protein A and peptide affinity chromatography.

Usage
Application	WB, IP, IHC, IF
Product Usage Information Dilution	Western Blotting (1:1000); Immunoprecipitation (1:50); Immunohistochemistry (1:50); Immunofluorescence (1:100)
MW (Target)	27 kDa

Background
Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes eIF6 is also shown to associate with the RNA-induced silencing complex (RISC) Deletion of eIF6 abolishes the miRNA-mediated gene silencing eIF6 may play its essential role in miRNA-mediated silencing by inhibiting translation initiation or ribosome recycling.

Background

Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes eIF6 is also shown to associate with the RNA-induced silencing complex (RISC) Deletion of eIF6 abolishes the miRNA-mediated gene silencing eIF6 may play its essential role in miRNA-mediated silencing by inhibiting translation initiation or ribosome recycling.

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