CAT. NO.: AMA-0506
| Target Information | |
|---|---|
| UniProt ID | P56537 |
| Product Details | |
|---|---|
| Size | 100 µL |
| Reactivity | Human, Mouse, Rat |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human eIF6. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IP, IHC, IF |
| Product Usage Information Dilution | Western Blotting (1:1000); Immunoprecipitation (1:50); Immunohistochemistry (1:50); Immunofluorescence (1:100) |
| MW (Target) | 27 kDa |
| Background | |
|---|---|
| Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes eIF6 is also shown to associate with the RNA-induced silencing complex (RISC) Deletion of eIF6 abolishes the miRNA-mediated gene silencing eIF6 may play its essential role in miRNA-mediated silencing by inhibiting translation initiation or ribosome recycling. | |
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