CAT. NO.: TK085
| General Info | |
|---|---|
| Size | 48-Strip-Wells / 96-Strip-Wells / 5×96-Strip-Wells / 10×96-Strip-Wells |
| Product Overview | This product constitutes a ready-to-use microwell and strip plate ELISA (enzyme-linked immunosorbent assay) Kit designed for the assessment of the Regulator of Telomere Elongation Helicase 1 (RTEL1) ELISA Kit target analytes within biological samples. The concentration gradients of the Kit standards or positive controls render a theoretical Kit detection range in biological research samples containing RTEL1. The ELISA analytical biochemical technique of the Kit is based on RTEL1 antibody-RTEL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RTEL1 antigen targets in samples. It's important to note that this ELISA Kit is specifically tailored for detecting native, not recombinant RTEL1. |
| Storage Conditions | Store all reagents at 2-8°C |
| Notes | Occasionally, trace amounts of reagent may remain in the closure of the product vial during shipment and storage of the RTEL1 ELISA kit. It is recommended that any liquid that may be present in the lid of the container be centrifuged to the bottom using a bench-top centrifuge prior to experimentation. |
| Reactivity | Donkey |
| Shipping Conditions | Dry Ice |
| Product Details | |
|---|---|
| Samples | Undiluted Body Fluids, Tissue Homogenates, Secretions |
| Target Info | |
|---|---|
| Molecular Weight | 119,494 Da |
| NCBI Accession | NP_001091044.1 |
| NCBI GenBank Nucleotide | NM_001097575.1 |
| NCBI GeneID | 505721 |
| NCBI Official Full Name | regulator of telomere elongation helicase 1 |
| NCBI Official Symbol | RTEL1 |
| NCBI Official Synonym Symbols | RTEL |
| NCBI Protein Information | regulator of telomere elongation helicase 1 |
| UniProt Gene Name | RTEL1 |
| UniProt Protein Name | Regulator of telomere elongation helicase 1 |
| UniProt Primary Accession | A4K436 |
| UniProt Secondary Accession | A4K3A3, A4K434, A4K435, A5J092 |
| Protein Family | Regulator of telomere elongation helicase |
| UniProt Comments | ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. |
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